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New Possibilities With
Non-surgical Solutions


Zeuterin™ (also labeled as EsterilSol™ in some countries) sterilizes male dogs by intratesticular injection. Composed of zinc gluconate neutralized by arginine, Zeuterin offers sterilization in one treatment, without general anesthesia, and without removing testicles. Launched in the U.S. in February 2014 by Ark Sciences, LLC, Zeuterin is presently the only non-surgical sterilant with U.S. Food & Drug Administration (FDA) approval.

Prior to U.S. launch and continuing today, ACC&D has sought to learn more about Zeuterin/EsterilSol. We have supported projects to explore how it is received by communities, study its potential impact on canine behavior, and share innovative strategies to incorporate Zeuterin into animal shelters/rescues and veterinary practices. The common thread among all these initiatives is ACC&D’s commitment to generate information about this new technology and help communities and individuals determine how it can best provide an alternative to castration, improve animal welfare and humanely reduce numbers of unwanted dogs.

Read on to learn about the product materials and information available on our website.

Product Profile and Position Paper: ACC&D's PPPP offers an objective and independent overview of Zeuterin, including its mechanism of action; use and effectiveness; health, safety, and behavioral considerations; and more. A recommended first stop for information on this product!  

ACC&D Symposia presentations: Our 3rd, 4th, and 5th International Symposia included multiple presentations, panels, and posters on Zeuterin and its predecessor, Neutersol. Here you can access all symposia resources on this topic for free.

"Neutersol" FOIA Summary: A resource available through the Freedom of Information Act summarizing product safety characteristics submitted to the US Food & Drug Administration (FDA) for approval. (Zeuterin has the same chemical composition as Neutersol but requires training and certification prior to purchase and use.)

"Prizes for Pioneers" Zeuterin Contest: We invited organizations and veterinarians using Zeuterin to share their best strategies for incorporating the product to sterilize more animals, use resources more effectively, and reach male dogs who otherwise would not be neutered. Thanks to generous sponsorship, we were able to offer grants to seven organizations using Zeuterin in creative and effective ways. Here you can view profiles of these organizations and learn about the strategies that they've implemented. We bet some of them could work for your organization!

World Spay Day Webinars: The World Spay Day team invited ACC&D's Joyce Briggs and Dr. Bob Weedon to conduct two webinars on Zeuterin in conjunction with World Spay Day and Spay/Neuter Awareness month. Check out the recorded webinars here.    

Reports from the field: Veterinarians, animal welfare organizations, and shelters are beginning to incorporate Zeuterin as a complement to surgical castration. Here you can read about organizations who have embraced particularly interesting and innovative ways of using Zeuterin to treat more animals and save more lives.    

Zeuterin, Castration, and Canine Behavior: How does Zeuterin influence behavior? What is the impact of castration on behavior? And how do both compare with intact animals? The reality is that we have very little objective information on these topics. ACC&D supported an initiative to gather data on free-roaming dog populations, the results of which may contribute to better understanding how different procedures can influence behavior.

EsterilSol Small Grants Program: Between 2009 and 2010, ACC&D offered small grants to five South American and African organizations. Funds supported work to increase sterilization capacity and improve understandings of field use of EsterilSol.

EsterilSol Guatemala field study: Todos Santos, Guatemala faces numerous obstacles to surgical castration: limited resources, primitive field conditions, and a cultural aversion to castration. ACC&D supported an innovative project to explore how EsterilSol might aid population control and animal welfare efforts in this community—and generate findings to help other communities facing similar challenges.

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