Zeuterin® Product Profile & Position Paper

Zeuterin® (marketed as Esterisol® in some countries) is a non-surgical sterilant for male dogs delivered via intratesticular injection. The Active ingredient is zinc gluconate neutralized with arginine. The formulation causes permanent sterility in one treatment. The process of neutering with Zeuterin/EsteriSol is also known as "zinc neutering." 

Notice: Zeuterin was commercially launched in the U.S. in 2014, following approval and use in several other countries by the name EsterilSol. The product, which was manufactured by Ark Sciences, is not currently being produced or distributed in any country due to the manufacturer’s financial challenges. While there is presently no indication of returning to the market, the formulation retains approval by the U.S. Food & Drug Administration (FDA). 

For additional resources, visit our Zeuterin page.